If you want to use the subtract operator '-', you need to convert your lists to NumPy arrays.
E.g.
>>> import numpy as np
>>> x=[12,13,14,15]
>>> y=[2,3,4,5]
>>> list(np.array(x)-np.array(y))
[10, 10, 10, 10]
You can also use subtract() function of Numpy for element-wise subtraction.
E.g.
>>> import numpy as np
>>> x=[12,13,14,15]
>>> y=[2,3,4,5]
>>> list(np.subtract(x,y))
[10, 10, 10, 10]