If you have the latest version of pandas installed on your computer, you can use its read_excel() function to read an excel file to get a dataframe.
Here is an example that reads a ".xlsx" file on Github and returns a dataframe.
import pandas as pd
df = pd.read_excel("https:/ /raw.githubusercontent.com/.../yourfile.xlsx")
To use the above code, replace the file URL with the actual URL.