If your file is not zipped, you can try the following awk command:
awk 'BEGIN{FS="\t";}{if ($column_number=="your_string") i++}END{print i}' filename
If your file is zipped, you can try the following awk command:
zcat zipped_file | awk 'BEGIN{FS="\t";}{if ($column_number=="your_string") i++}END{print i}'
Replace column_number with the column number in your file and your_string with your special string.